When iodinated contrast is administered via nonvascular routes, systemic absorption of these contrast agents is low and has few known adverse reactions. However, there are reports of reactions with these agents, so some degree of systemic absorption can occur. Most contrast drains from the cavity after the conclusion of the procedure. There is a paucity of information regarding concentration of nonvascularly administered contrast agents in breastmilk and guidelines on breastfeeding after such procedures are not available. However, based on very low systemic absorption rates and known low excretion of intravenously administered contrast into breastmilk, we do not recommend routine interruption of breastfeeding for these types of procedures.